Acute Lymphoblastic Leukemia: Prognosis

Acute Lymphoblastic Leukemia(ALL) is a type of blood cancer affecting the white blood cells of the immune system. This article discusses about the

Acute Lymphoblastic Leukemia’s prognosis.

What Causes Acute Lymphoblastic Leukemia?

The word acute refers to the characteristic of the cancer which becomes fatal in shorter time duration if it is not treated. Lymphoblasts are the white blood cells which is in their immature state and turns malignant causing the disease. After maturing, these cells are known as Lymphocytes. Environmental factors like drugs, chemicals or radiations change the chemical structures known as genes which are made up of DNA molecules. The genes follows the instructions described by the healthy cells to perform their tasks. Mutation in their structure can cause the change in their functioning. When changes takes place in the DNA, there can be an abnormality in sending and receiving signals which are related with the growth of cells. There is also a possibility of these cells being disrupted. Hence, its more clear that ALL is mainly caused due to chemical mutation and radiation.

Acute Lymphoblastic Leukemia: Prognosis

Due to clinical trials on the new drugs and chemotherapeutic agents, the survival rate of ALL has improved from zero to 20-75 percentages in these four decades. This is even due to the stem cell transplant technology. Treatments for the genetic characteristic of the blast cells and the new drugs have improved the prognosis rate.

Prognosis for ALL

differs for every individual depending on certain factors like:

  • Gender:

    Females have shown better results than male.

  • Age of Diagnosis:

    Children in the age group of 1-10 years are likely to be cured better and faster than the older patients. In older patients ALL mostly occurs due to chromosomal abnormalities and hence its more difficult to treat.

  • Ethinicity:

    Caucasians are more prone to ALL than the Africans, Americans. Asians have shown good results for prognosis than the non- Caucasian.

  • If cancer has spread to CNS then the prognosis is very poor.

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