What is Mantle Cell Lymphoma – Symptoms, Diagnosis and Treatments

Non-Hodgkin’s Lymphomas are a group of blood cancers. 6 percent cases of class comprise of a rare ailment known as

mantle cell lymphoma (MCL)

. According to estimation, there are 15000 people suffering from this disease in the United States. It is rarely cured and the treatment is very difficult. Owing to the advancement in research, the patients are surviving for 6 years instead of the earlier 3 years survival rate. The cause of MCL is unknown.

Mantle cell lymphoma

Symptoms of Mantle Cell Lymphoma:

  • Fever
  • Unexplained weight loss
  • Heavy sweating at night times
  • Swelling of spleen
  • Swelling of the lymph nodes
  • Lump in the neck
  • Lump in the groin
  • Lump in the arm pit
  • Gastro-intestinal tract is affected
  • Liver is affected
  • Bone marrow is affected

Men are four times more affected by this cancer than female. It is neither communicable nor inherited. Most of the patients are in their early 60s. The disease, unfortunately, is diagnosed in its advanced stage. Translocation of a part of a gene causes the development of this cancer. But, it is not known through research studies why this undesirable development in the gene’s chromosome t(11;14)(q13;q32) takes place.


As a part of diagnosis of the ailment, the bone marrow, gastro-intestinal tract and the colon are regularly checked. Computer tomography scans of the chest, neck, pelvic and the abdomen are carried out regularly. A technique called lumber puncture is carried out which involves collection of fluid from the spine to find the presence of malignant cells in the region. PET scan when combined with CT scan forms the most effective diagnostic technique to find the progression of the disease.

Treatment of Mantle Cell Lymphoma:

Unfortunately, there is no proven treatment for MCL. The patients enroll themselves with the available latest treatments to get the maximum benefits.

Some of these modalities are chemotherapy, radioimmunotherapy, immune based therapy and new biologic agents. Relapse is a challenging part of the treatment. But, there are techniques available to treat it along with new approaches under test.

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