Cancer

What are Chronic Granulocytic Leukemia Symptoms?

Chronic granulocytic leukemia symptoms

are asymptomatic by nature. The condition represents a type of cancer of the white blood cells. Large numbers of these immature cells of the immune system grow rapidly in the bone marrow and the blood posing threat to the life of the individual. It has three phases namely the chronic phase, accelerated phase and the blast phase.

85 percent cases of this cancer are diagnosed in chronic phase and targeted therapies now available have increased the survival rate by 90 percent. Unfortunately, there is no cure or treatment if the disease is found to be in the accelerated or blast phase.

Philodelphia chromosome

What are Chronic Granulocytic Leukemia Symptoms?

  • Asymptomatic or without any signs in the initial stages
  • Increased count of the white blood cells
  • Swollen spleen which represents the body is under a serious threat
  • Pain on the left side of the body
  • Hip pain
  • Joint pain
  • Malaise
  • Susceptible to infections
  • Low grade fever
  • Anemia – Low count of the red blood cells which carry oxygen and nutrients to the rest of the body
  • Easy bruising
  • Thrombocytopenia – Low count of the platelets in the blood

Apart from the known cause of Philodelphia chromosome abnormality, disruption in other chromosomes lead to the advancement of the disease to accelerated and blast phases. In such stage, the symptoms are that of acute leukemia. These signs are:

  • Fatigue
  • Paleness
  • Shortness of breath
  • Minor trauma leading to bleeding
  • Influenza
  • Loss of appetite
  • Weight loss
  • Bone pain
  • Frequent infections
  • Swelling of the gums
  • Petechiae – Spots on the skin caused by bleeding
  • Swelling of the Lymph nodes, though rare
  • Leukemia cutis found in 10 percent patients
  • Tumor outside the bone marrow technically called the chloroma

Conclusion:

Different organs of the body are involved in the

chronic granulocytic leukemia symptoms

. This feature is owing to the fact that exposure to the harmful radiations cause abnormality in the chromosomes of the affected cells.

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