Symptoms of Plasma Cell Leukemia (PCL)

Plasma cells are certain types of white blood cells which produce antibodies excessively. When the cancer ailment targets these cells, symptoms of plasma cell leukemia become apparent. These cells are produced in the bone marrow and upon maturation reach the organs called lymph nodes which are the garrisons of immune system cells.

The cancer is considered as one of the most aggressive forms of this ailment and leaves very less time to undergo treatment.

Symptoms of Plasma Cell Leukemia (PCL):

  • Weakness
  • Fever Bone Pain
  • Kidney Failure
  • Enlarged liver
  • Mental confusion
  • Enlarged spleen
  • Palpitation
  • Loss of appetite
  • Leukocytosis – A condition where large numbers of white blood cells are produced in the body abnormally much beyond the desired level.
  • Lymphadenopathy – Swelling of the lymph nodes which denote that the body is under serious threat from external invasion.

Facts to Know on Plastic Cell Leukemia (PCL):

  • If the presence of the rogue PCL cells is more than 20 percent in the blood or the count is more than 2 x 10<sup>9</sup>/L, a person is diagnosed with this cancer. This criterion is as per the issued guidelines of the World Health Organization.
  • Surgery, radiation therapy and chemotherapy are the conventional treatments for cancer while fall short of providing remedy for PCL.
  • Owing to this reason, the chance of recovery or prognosis is very poor for this cancer.
  • 60-70 percent cases the cancer is of the primary type and the expected time left for a patient after diagnosis is less than 8-12 months.
  • In spite of poor results, chemotherapy along with supportive care is the treatment available for this cancer which strives to improve the quality of life of the patient with varying results.
  • Certain research studies have found that stem cell transplantation has better chances of treating people with symptoms of plasma cell leukemia primary in comparison to the other available remedies.
  • Those with secondary form of this cancer have very low prognosis or survival rate than the primary PCL patients.


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